Description

Biotalent is working with an early-stage biotech company that is focused on developing precision medicines for genetically defined neurological and immunological diseases. The Company’s culture is driven by collaboration and innovation, starting with an experienced leadership team tasked with navigating development paths in partnership with leading academics, clinicians, investors, patient advocacy groups, and regulatory agencies worldwide.

As a member of the DMPK group, the candidate is to conduct absorption, distribution, metabolism, excretion (ADME) studies to support the discovery and development of drug candidates. She/he will have opportunities for career growth through acquisition of new skills, experiences, and professional relationships in a fast-paced environment.

Responsibilities:

• Prepare biological samples (plasma, tissues, and cells) for analysis
• Analyze biological samples using LC-MS/MS
• Develop/review analytical methods and troubleshoot as needed
• Process, record, and manage experimental data
• Review and upload ADME data from CROs to research portal
• Summarize results in memo, report, and/or slide formats
• Participate in group meetings, present results, and interpret data
• Understand and follow standard operating protocols and laboratory requirements to conduct work safely
• Coordinate and track external DMPK studies at various CRO
• Prepare/review ADME reports for regulatory filings
• Capable of prioritizing a diverse workload with strong time management skills
• Team-oriented, enthusiastic, and flexible

Requirements

• BS/MS degree with 5-15 years of industry experience or Ph.D. with 0-5 years of industry experience with major in Chemistry, Biology, Pharmacology, Pharmaceutical Sciences, Biochemistry, or related experience in industry or academia.
• Excellent communication skills (both verbal and technical) and interpersonal skills are required.
• Ability to troubleshoot and optimize assays as needed, identifying, and applying novel techniques or protocols from reports in the scientific literature
• Experience with sample preparation automation is desirable
• General instrument competency including troubleshooting and problem-solving skills
• Experience working as the DMPK representative in project teams is a plus
• Hands-on bioanalysis experience using LC-MS/MS required
• Execute, analyze, and interpret in vitro assays to support the advancement of drug candidates
• Working knowledge and hands-on experience working with recombinant cell lines, primary cells, and human/ animal samples; experience with primary hepatocytes (culture and/or suspension) preferred
• General computer skills including MS Office; pharmacokinetic analysis (example - noncompartmental analysis with Phoenix WinNonlin) desirable

The Company is proud to be an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital and veteran status.

The Company requires employees and guests who enter our workspace to be vaccinated against COVID-19. If there is a medical condition or religious belief that prevents an employee from being vaccinated, the Company will consider whether we can make a reasonable accommodation.