Posted 21 January 2023
LocationUnited Kingdom
Job type Contract
Contact NameGreg Hammond

Job description

We are currently searching for a Principal Computational Chemist to join a rapidly growing Cambridge-based Biotech on a 6 month contract.They are working in one of the hottest areas of drug discovery and they have a range of advantages over competing therapeutic strategies.  

This role will offer you

  • Opportunity to be key member of the informatics teams and consult on platform projects, utilising your expertise in Computational Chemistry and Data Analytics.
  • Opportunity to work with a fast growing team, operating the cutting edge of drug discovery and novel modalities.  

You will be responsible for

  • Providing computational chemistry input to specific drug discovery projects including molecular modelling & docking through to cheminformatic analyses and predictive model building.
  • Working closely with medicinal chemists and wider project teams to critically analyse project data and contribute ideas that will drive projects forward.
  • Collation and analysis of complex, multi-parametric datasets to rationalise SAR and build predictive models in areas such as biological activity, selectivity, in vivo properties and others.
  • Providing computational analyses and solutions to projects via your own personal contributions as well as by working with external vendors or collaborators where appropriate

You will bring the following

  • PhD in related field with at least 3 years of computational chemistry experience working in a pharma, biotech or academic drug discovery unit.
  • Experience of structure-based and ligand-based design using one or more of shape, fingerprint and pharmacophore-based methods including library design & enumeration and lead-hopping.
  • A working knowledge of the Dotmatics suite of tools and other languages/ environments including Python, R, Linux & HPC would be very advantageous.