Associate Director, Protein Engineering

Posted 10 January 2023
Job type Permanent
Contact NameCaleb Clarkson

Job description

BioTalent is excited to partner with a venture-backed biotech focused on combating neurodegenerative diseases through the use of complex protein biologics. Their mission is to promote brain health and repair through genetic and biochemical insights.


You Will:

  • Lead efforts to optimize stability, minimize immunogenicity and improve the properties of corresponding lipoproteins
  • Create hypothesis-driven libraries of apolipoproteins with varying biochemical and biophysical properties to assess their influence on pharmacokinetics and pharmacodynamics
  • Collaborate with the broader research team, external collaborators, and/or CROs to produce, formulate, characterize, and test candidates
  • Lead efforts in developing lab-based and in silico methods for improvement of data generation and the throughput of material production
  • Inform future rounds of protein engineering through the analyses of data from multiple sources
  • Present findings and regularly communicate with the larger research and management teams



  • Ph.D. & 6+ years of biotech/pharma industry experience in Biology, Biomedical Engineering, Biochemistry, Biophysics, or related field
  • Hands-on expertise in protein/antibody/enzyme engineering, including both directed evolution and rational design
  • Record of successful management and collaboration with CRO’s in the past
  • Knowledge of methods commonly used to characterize biologics


Desired Experience:

  • Familiarity with methods to characterize nanoparticles
  • Experience with bioconjugation or crosslinking chemistry
  • Familiarity with lipoprotein biology or biochemistry
  • Experience with barcoded libraries


For more information about this opportunity, please apply to the role directly or contact Caleb Clarkson at: